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Master SERP+ Programme - cohort 2020-2025
The molecules of life: from structure to chemical function (3 ECTS)
Semester 1
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All courses during this semester
Semester 2
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All courses during this semester
- Transferable skills: Polish course, Summer School in Entrepreneurship (6 ECTS)
- The molecules of life: from structure to chemical function (3 ECTS)
- Selected in silico and in vitro methods in thermodynamics and soft matter (6 ECTS)
- Organic chemistry (3 ECTS)
- Introduction to solid state (6 ECTS)
- Dynamics of photochemical reactions in chemistry, biology and medicine (6 ECTS)
- Transferable skills: Portuguese course, Summer School in Entrepreneurship (6 ECTS)
- Solid State Physics (6 ECTS)
- Molecular Energetics (3 ECTS)
- Laboratory of Materials and Surface Analysis (6 ECTS)
- Interfacial Electrochemistry (3 ECTS)
- Interfaces, Colloids and Self-Assembly (6 ECTS)
- Transferable skills: Summer School in Entrepreneurship (3 ECTS)
- Organic Photochemistry (3 ECTS)
- Italian Courses (3 ECTS)
- Introduction to Solid State (6 ECTS)
- Inorganic Functional Materials (3 ECTS)
- Electrochemical systems for energy conversion and storage (6 ECTS)
- Chemistry and Technology of Catalysis and Laboratory (6 ECTS)
Semester 3
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All courses during this semester
- Transferable skills: Scientific writing, French courses - 5ECTS
- Nanosciences (6 ECTS)
- Nanoparticles and Advanced radiation therapies (6 ECTS)
- Fundamentals in data science and machine learning (3 ECTS)
- Femtochemistry (3 ECTS)
- Chemistry for renewable energy: from advanced research to industrial applications (6 ECTS)
- Transferable skills: Scientific writing, Polish courses (6 ECTS)
- Lanthanide luminescence: Application in chemistry and biology (6 ECTS)
- Introduction to Data Sciences (3 ECTS)
- Environmental photochemistry (3 ECTS)
- Computational and quantum photochemistry (6 ECTS)
- Applied photochemistry and luminescence spectroscopy (6 ECTS)
- Scientific Writing and Career Objectives (3 ECTS)
- Portuguese course (3 ECTS)
- Nanotechnologies, Micro and Nano-fabrication (6 ECTS)
- Materials Properties and Applications (6 ECTS)
- Electrochemical Technology (6 ECTS)
- Data Science Basics (3 ECTS)
- Bionanotechnology (3 ECTS)
- Transferable skills: Scientific Writing Industrial Seminars (3 ECTS)
- Surface Science and Nanostructuring at Surfaces (6 ECTS)
- Polymers for electronics and energy harvesting (6 ECTS)
- Laboratory on device building (3 ECTS)
- Italian Courses (3 ECTS)
- Data Science and Applications to Chemistry (3 ECTS)
- Composite materials for biomedical applications (6 ECTS)
Content
The students will understand how the atomic structure of biological molecules is discovered and how this knowledge is applied in modern drug discovery. If interested in this subject - they may continue their careers in the drug development industry.
Auditorium lectures
- Principles of protein structure.
- Classification of protein folds.
- Anatomy and taxonomy of nucleic acids and macromolecular complexes.
- Overview of experimental methods of structural biology: cryo-EM.
- Principles of macromolecular crystallography.
- Protein handling and crystallization.
- Phasing methods in macromolecular crystallography.
- Electron density maps and model building.
- Protein Data Bank (PDB) and model validation.
- Examples of structure-based drug design.
Laboratory practicals
- Protein handling and crystallization including robotic crystallization.
- Protein crystal handling, cryoprotection and X-ray diffraction experiments.
- Electron density maps and their interpretation.
- PDB and bioinformatics tools for protein analysis.
- An exercise in structure-guided drug design.
- Protein model building.
Journal club
- 5 meetings with student seminars presenting assignments from current literature with discussion.
Aims
The students will understand how the atomic structure of biological molecules is discovered and how this knowledge is applied in modern drug discovery.
Recommended Books
- Gale Rhodes, Crystallography Made Crystal Clear, 3rd edition, Academic Press, Amsterdam 2006.
- Bernhard Rupp, Biomolecular Crystallography, Garland Science, New York 2010.
- Arthur Lesk, Introduction to Protein Science, Oxford University Press 2010.
- Carl Branden & John Tooze, Introduction to Protein Structure, 2nd edition, Garland Publishing, New York 1996.
Teaching Staff
Prof. Mariusz Jaskolski
Dr. Szymon Krzywda
Hours
Lectures: 15h
Practical: 30h