Soluble and insoluble polymers. Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports. Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods. Combinatorial chemistry: use and applications. Parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests.
The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science.
“Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3
“Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6