Applications for the class of 2017-2019 are now closed.

Applications for the class of 2018-2020 will open in October 2017.

Master SERP+ Programme

Combinatorial chemistry and solid phase synthesis


Soluble and insoluble polymers. Resins for solid-phase synthesis: preparation, characterization, loading, properties. Macroscopic solid supports. Solid phase synthesis: handles, linkers, loading and cleavage strategies, examples of organic reactions, analytical methods. Combinatorial chemistry: use and applications. Parallel and mix&split synthesis. Deconvolutive methods and tagging. On-bead and off-bead tests.


The course is aimed at giving basic knowledge about modern techniques and approaches to prepare large collections of compounds for applications in medicine, catalysis and material science.

Recommended Books

“Solid-phase synthesis and combinatorial technologies” P. Seneci; Wiley Interscience, New York. ISBN 0-471-33195-3

“Solid phase peptide synthesis : a practical approach” E. Atherton, R.C. Sheppard; Oxford University Press. ISBN 0-19-963066-6 

Teaching Staff

Prof. Andrea Basso (Course Coordinator)


Lectures: 24 h

Grading System

Exam: 80%

Presentations: 20%