Applications for the class of 2017-2019 are now closed.

Applications for the class of 2018-2020 will open in October 2017.

Master SERP+ Programme

Introduction to biophysics and bio-informatics


Content

Introduction to biology

  • Cell biology (From DNA to proteins, Cell architecture and motility, The Cell cycle)
  • Biochemistry (The elementary bricks of life: proteins, DNA, RNA, membrane/lipids)

Biophysics

  • Fluorescence Imaging, Fluorescent probes for biology,
  • Principe of a microscope,
  • Analysis of molecular behaviors in live cell using fluorescence imaging,
  • Biophysics of membranes,
    • Membrane transport: vesicle fusion, ion gradient concentration and biological examples,
    • Patch-clamp technique for measuring ionic properties of cells membranes.
  • Introduction to Atomic Force and Transmission Electron Microscopies,
  • Electron microscopy
    • Scanning and Transmission Electron Microscopy
    • Application to biophysics: DNA, protein structure, cell structure, local cell ionic concentration
    • Atomic Force Microscopy (AFM): Theory and application of AFM.
  • Single molecule studies (DNA imaging, biopolymer elasticity).

Practical courses

  • Bioinformatics: Visualisation and manipulation of biomolecule structures

Lab training

  • Cell staining and observation in optical microscopy
  • AFM measurements on DNA

Aims

Give some knowledge on biophysics concepts and standard methods. Illustrate the importance of chemistry at the interface between biology and physics

Teaching Staff

Marie Erard (Course Coordinator)
Sophie Dupré
Oliver Nüsse
Olivier Piètrement

Hours

Lecture: 27 h
Practical courses: 14 h

Grading System

Final exam: 55 %
Practical course: 45 %